Evaluation of the Anti-pyretic Effects of Ethanolic Extract of Sonchus wightianus DC Using Wistar Rats

This study aimed to investigate the ethanolic extract of Sonchus wightianus DC for its pharmacological activities, including anti-pyretic, behavioral, and immunomodulatory effects. The extract was prepared via Soxhlet extraction, and its chemical composition was analyzed for bioactive compounds. The extract demonstrated significant antipyretic effects in both yeast-induced and vaccine-induced hyperpyrexia models in rats. Furthermore, behavioral tests revealed an increase in ambulation and rearing frequency compared to the negative control group. Additionally, a notable reduction in white blood cell (WBC) count was observed, suggesting potential immunomodulatory properties. These results support the medicinal potential of Sonchus wightianus DC in treating fever and modulating immune responses.